Heparin fractions of lower or higher molecular weight can be obtained by gel filtration and/or ion
exchange chromatography.
As compared to commercial heparin, HEPARIN FRACTION 1 [PZ-0302] has a slightly higher
average molecular weight and exhibits an increased inhibition of thrombin and Factor Xa.
HEPARIN FRACTION 2 [HR-0340] has a lower average molecular weight and lower activity.
References
Cardin AD, Jackson RL. Heparin fraction with anti-HIV activity, US Patent 5,272,261.
Laurent TC, Tengblad A, Thunberg L, Höök M, Lindahl U. The molecular weight dependency of
the anticoagulant activity of heparin. Biochem J 1978; 175: 691.
Cardin AD, Taylor DL, Krstenansky JL, Tyms AS, Jackson RL. A heparin which binds to the
envelope glycoprotein gp120 inhibits human immunodeficiency virus replication. Trans Ass Am
Phys 1989, CII:101-109.
Sache E, Maillard M, Bertrand H, Choay J, Fareed J, Andersen AC. Studies on a highly potent
anticoagulant high molecular weight fraction isolated from porcine heparin. Chemistry and
Biology of Heparin. Roger L. Lundblad, W. Virgil Brown, Kennth G. Mann, Harold R. Robert,
Eds. Elsevier/North Holland 1981; pp. 645-658.
Ekre HP, Carlson J, Kulane AA, Perlmann P, Wahlgran M, Wahlin B. Heparin fractions having
low affinity for antithrombin III for treating malaria. US Patent 5472953 (1995).
Hemker HC, Beguin S, Kakkar VV. Can the haemorrhagic component of heparin be identified?
Haemostasis 1996; 26:117-126.
